DOSAGE OF PROLACTINE IN NORMAL AND PATHOLOGICAL SUBJECTS

Abstract

Homologous radioimmunoassay of human prolactin was performed. During the menstrual cycle, prolactin levels are more elevated during the ovulatory and luteal phases than during the follicular phase. During pregnancy, prolactin levels progressively increase to reach their maximum at the end of gestation; during lactation, prolactin levels increase for the 2 days following delivery, then progressively decrease; bromocryptine oral administration drastically reduces prolactin levels within the 24 h; it inhibits the prolactin release normally induced by suckling. Assays of prolactin are useful to define the role of this hormone in the genesis of the galactorrhea. Bromocryptine, like L-dopa, reduces hyperprolactinemia, either functional or tumoral in origin. Thyrotropin releasing hormone provokes prolactin release which is more pronounced in females than in males.