Mutation frequencies in male mice and the estimation of genetic hazards of radiation in men.
- 1 January 1982
- journal article
- research article
- Published by Proceedings of the National Academy of Sciences in Proceedings of the National Academy of Sciences
- Vol. 79 (2), 542-544
- https://doi.org/10.1073/pnas.79.2.542
Abstract
Estimation of the genetic hazards of ionizing radiation in men is based largely on the frequency of transmitted specific-locus mutations induced in mouse spermatogonial stem cells at low radiation dose rates. The publication of new data on this subject has permitted a fresh review of all the information available. Although mutation frequency decreases markedly as dose rate is decreased from 90 to 0.8 R/min (1 R = 2.6 .times. 10-4 C/kg) there seems to be no further change < 0.8 R/min over the range from that dose rate to 0.0007 R/min. Simple mathematical models are used to compute a maximum likelihood estimate of the induced mutation frequency at the low dose rates and a maximum likelihood estimate of the ratio of this to the mutation frequency at high dose rates in the range of 72-90 R/min. In the application of these results to the estimation of genetic hazards of radiation in man, the former value can be used to calculate a doubling dose; the dose of radiation that induces a mutation frequency equal to the spontaneous frequency. The doubling dose based on the low-dose-rate data compiled here is 110 R. The ratio of the mutation frequency at low dose rate to that at high dose rate is useful when it becomes necessary to extrapolate from experimental determinations, or from human data, at high dose rates to the expected risk at low dose rates. The ratio derived from the present analysis is 0.33.This publication has 7 references indexed in Scilit:
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