Effect of Certain Histaminase Inhibitors on Gastric Secretion
- 30 September 1958
- journal article
- research article
- Published by American Physiological Society in American Journal of Physiology-Legacy Content
- Vol. 195 (1), 209-215
- https://doi.org/10.1152/ajplegacy.1958.195.1.209
Abstract
Dogs with Heidenhain pouches were used to study the effect of aminoguanidine (AG) and iproniazid (IPN) (1-isonicotinyl-2-isopropylhydrazine) (‘Marsilid’) on gastric secretion. AG and IPN given subcutaneously or orally were found to stimulate the basal secretion and to augment the gastric secretory response to a meal. In vitro studies have shown that AG is a diamino oxidase (DO) inhibitor and IPN is both a di- and monoamino oxidase (MO) inhibitor. IPN augments gastric secretion by its DO and not its MO inhibitor activity. Doses of IPN which cause evidences of mild toxicity depress gastric secretion. Evidence of the accumulative action of IPN on gastric secretion was obtained. Dogs vary considerably in their sensitivity to iproniazid. Since inflammation increases sensitivity to the gastric augmentory effects of both AG and IPN, and since man is 10 times more sensitive to histamine than the dog, it is suggested that the use of iproniazid in the treatment of active tuberculosis should augment gastric secretion, unless evidences of toxicity occur, and that the drug should be used cautiously in peptic ulcer patients. B1-pyrimidine, a DO inhibitor, given subcutaneously slightly augments the secretory response to a meal in a sensitive dog.Keywords
This publication has 15 references indexed in Scilit:
- DIAMINE OXIDASE AND CADAVERINE METABOLISMJournal of Biological Chemistry, 1954
- STUDIES ON HISTAMINE-METABOLIZING ENZYMES IN INTACT ANIMALS. IIJournal of Biological Chemistry, 1953
- THE EFFECT OF B1‐PYRIMIDINE ON GASTRIC SECRETIONQuarterly Journal of Experimental Physiology and Cognate Medical Sciences, 1953
- Influence of isonicotinic acid hydrazide (INH) and 1-isonicotinyl-2-isopropyl hydrazide (IIH) on bacterial and mammalian enzymesCellular and Molecular Life Sciences, 1952
- Zur Hemmung der Diaminooxydase (Histaminase)Cellular and Molecular Life Sciences, 1952
- Urinary Excretion of Hydrazine Derivatives of Isonicotinic Acid in Normal HumansExperimental Biology and Medicine, 1952
- PHARMACOLOGIC AND TOXICOLOGIC OBSERVATIONS ON HYDRAZINE DERIVATIVES OF ISONICOTINIC ACID (RIMIFON, MARSILID)Published by Elsevier ,1952
- THE EFFECT OF SOME COMPOUNDS RELATED TO HISTAMINE ON GASTRIC ACID SECRETION1952
- DOSES OF HISTAMINE PRODUCING MINIMAL AND MAXIMAL GASTRIC SECRETORY RESPONSES IN DOG AND MANAmerican Journal of Physiology-Legacy Content, 1948
- Über den enzymatischen Abbau von Histamin und Diaminen. 2. MitteilungHelvetica Chimica Acta, 1938