Brain Acetylcholine Synthesis Declines with Senescence
- 7 August 1981
- journal article
- research article
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 213 (4508), 674-676
- https://doi.org/10.1126/science.7256270
Abstract
The synthesis of whole brain acetylcholine is reduced in two strains (C57BL and BALB/c) of senescent mice. The incorporation of [U-14C]glucose into acetylcholine decreased in both strains by 40 +/- 4 per cent in 10-month-old mice and by 58 +/- 9 percent in 30-month-old mice compared with mice 3 months old. The incorporation of [2H4]choline into acetylcholine declined 60 and 73 percent in 10- and 30-month-old mice, respectively. Deficits in the cholinergic system may contribute to brain dysfunctions that complicate senescence.This publication has 25 references indexed in Scilit:
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