Brain Metabolism During Hypoglycemia
- 1 March 1973
- journal article
- research article
- Published by American Medical Association (AMA) in Archives of Neurology
- Vol. 28 (3), 173-177
- https://doi.org/10.1001/archneur.1973.00490210053006
Abstract
Adenosine triphosphate (ATP), phosphocreatine, glucose levels, and metabolic rates were measured in several regions of the central nervous system (CNS) of normal and hypoglycemic (insulin) mice. Following insulin treatment, there was a progressive deterioration of neurological function, a uniform, marked decrease of glucose reserves, and a uniform depression of metabolic rate throughout the CNS; however, ATP and phosphocreatine levels were unaltered. These results indicate that the functional encephalopathy resulting from hypoglycemia is not due to a lack of chemical energy. Also, the present results indicate that the clinically apparent depression of neural function in progressively descending levels of the CNS during hypoglycemia is not a result of a depletion of glucose reserves or depression of metabolic rate more rapidly in the rostral portions of the CNS than in the more caudal portions.Keywords
This publication has 5 references indexed in Scilit:
- CEREBRAL CARBOHYDRATE METABOLISM DURING ACUTE HYPOXIA AND RECOVERY1Journal of Neurochemistry, 1972
- THE EFFECT OF ELECTROSHOCK ON REGIONAL CNS ENERGY RESERVES IN MICE1Journal of Neurochemistry, 1971
- Cerebral high-energy phosphates during insulin hypoglycemiaAmerican Journal of Physiology-Legacy Content, 1962
- Cerebral Blood Flow and Cerebral Oxygen Consumption During HypothermiaAmerican Journal of Physiology-Legacy Content, 1954
- EFFECT OF INSULIN HYPOGLYCEMIA ON GLYCOGEN CONTENT OF PARTS OF THE CENTRAL NERVOUS SYSTEM OF THE DOGArchives of Neurology & Psychiatry, 1944