Impaired Responsiveness to NO in Newly Diagnosed Patients With Rheumatoid Arthritis

Abstract
Objective— Cardiovascular disease is the major cause of excessive mortality in patients with rheumatoid arthritis (RA). We determined whether endothelial dysfunction characterizes patients with newly diagnosed RA (n=10) compared with normal subjects (control group, n=33) and whether it is reversible with 6 months of anti-inflammatory therapy.