Initiator constitutive mutation with an ‘up-promoter’ effect in Aspergillus nidulans
- 1 March 1975
- journal article
- Published by Springer Nature in Nature
- Vol. 254 (5495), 31-34
- https://doi.org/10.1038/254031a0
Abstract
A mutation leading to strong constitutivity for a uric acid-xanthine permease in the lower eukaryote Aspergillus nidulans has been found to be tightly linked to the putative structural gene whose expression it controls in the cis configuration. In addition, it increases the maximal induced level of transport 2.5-fold. This is the first demonstration of an initiator or promoter mutation in an eukaryote.Keywords
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