P-Glycoprotein-Dependent Disposition Kinetics of Tacrolimus: Studies in mdr la Knockout Mice
- 1 January 1999
- journal article
- Published by Springer Nature in Pharmaceutical Research
- Vol. 16 (8), 1213-1218
- https://doi.org/10.1023/a:1018993312773
Abstract
Purpose. This study was performed to evaluate the involvement of P-glycoprotein in disposition kinetics of tacrolimus (FK506), a substrate of P-glycoprotein, in the body. Methods. The blood and...Keywords
This publication has 27 references indexed in Scilit:
- Active Secretion of Drugs from the Small Intestinal Epithelium in Rats by P-Glycoprotein Functioning as an Absorption BarrierJournal of Pharmacy and Pharmacology, 1996
- Clinical Pharmacokinetics of TacrolimusClinical Pharmacokinetics, 1995
- Absence of the mdr1a P-Glycoprotein in mice affects tissue distribution and pharmacokinetics of dexamethasone, digoxin, and cyclosporin A.Journal of Clinical Investigation, 1995
- Immunophilins mediate the neuroprotective effects of FK506 in focal cerebral ischaemiaNature, 1994
- Disruption of the mouse mdr1a P-glycoprotein gene leads to a deficiency in the blood-brain barrier and to increased sensitivity to drugsCell, 1994
- Detection of the FK506-FKBP-Calcineurin Complex by a Simple Binding AssayBiochemical and Biophysical Research Communications, 1993
- INHIBITION OF THE MULTIDRUG EFFLUX PUMP IN ISOLATED HEPATOCYTE COUPLETS BY IMMUNOSUPPRESSANTS FK506 AND CYCLOSPORINETransplantation, 1993
- Calcineurin is a common target of cyclophilin-cyclosporin A and FKBP-FK506 complexesCell, 1991
- Transport of α-Aminoisobutyric Acid across Brain Capillary and Cellular MembranesJournal of Cerebral Blood Flow & Metabolism, 1983
- Moment analysis for disposition kinetics of several cephalosporin antibiotics in ratsJournal of Pharmacy and Pharmacology, 1983