A New Method for Coating Glass Beads for Use In Gas Chromatography of Chloropromazine and Its Metabolites

Abstract

Because of their inert character, glass beads provide good support material for columns having low liquid/solid ratios, but it has been difficult to reproduce these packings. This paper describes a new method for coating glass beads with a mixture of liquid phases and particles of diatomaceous earth which is reproducible and improves column efficiency. The technique has been applied to the preparation of column packings for the gas chromatography of chlorpromazine and its metabolities. Column packings of this type are particularly useful for gas chromatographing heat labile compounds.