A New Approach for Controlling the Release Rate of Pheniramine Aminosalicylate Via Solid Dispersion in Different Types of Eudragit

Abstract

Co-precipitates of pheniramine aminosalicylate [antihistamine] in different types of Eudragit were prepared. IR spectra indicated the absence of molecular interaction between the drug and Eudragit. The effect of polymer type on the retardation of drug release rate was in the following order: Eudragit S 100 > Eudragit L 100 > Eudragit RSPM or Eudragit RS 100 > Eudragit RLPM or Eudragit RL 100. The concentration of the polymer in the system was a determining factor in controlling the release rate of the drug. As the concentration of the polymer in the system increased, the release rate of the drug decreased. Co-precipitates of the drug in different ratios of Eudragit blends were also prepared. The release rate of the drug decreased by decreasing the concentration of the permeable Eudragit RLPM or Eudragit RSPM in the system. The rapid release rate of the drug from the physical mixtures excluded their application in controlling drug release.