Multilocus genetic structure in natural populations of Escherichia coli.
- 1 March 1983
- journal article
- research article
- Published by Proceedings of the National Academy of Sciences in Proceedings of the National Academy of Sciences
- Vol. 80 (6), 1751-1755
- https://doi.org/10.1073/pnas.80.6.1751
Abstract
A survey of allozyme variation at 12 enzyme loci in 1705 clones of the genetic species E. coli (including 4 Shigella spp.) from natural populations revealed 302 unique allele combinations (electrophoretic types). Single-locus diversity estimates fall within the range predicted by the neutral allele theory of molecular evolution, but the combinations of alleles in electrophoretic types are highly nonrandom, as indicated by a test of association over all loci and by evidence of complex linkage disequilibria in several 4-locus combinations. These linkage disequilibria reflect genetic differentiation of E. coli into 3 groups of strains. Because of restricted recombination, the stochastic extinction of lines and selective differences between particular genetic combinations may have contributed to the evolution of subspecific structure in E. coli.This publication has 34 references indexed in Scilit:
- Linkage disequilibrium due to random genetic drift in finite subdivided populationsProceedings of the National Academy of Sciences, 1982
- Genetic Diversity and Relationships among Strains of Escherichia coli in the Intestine and Those Causing Urinary Tract InfectionsPublished by S. Karger AG ,1982
- Genetic variability and effective population size when local extinction and recolonization of subpopulations are frequentProceedings of the National Academy of Sciences, 1980
- Genetic Diversity and Structure in Escherichia coli PopulationsScience, 1980
- Linkage map of Escherichia coli K-12, edition 6.1980
- The kinetics of conjugative plasmid transmission: Fit of a simple mass action modelPlasmid, 1979
- F‐statistics and analysis of gene diversity in subdivided populationsAnnals of Human Genetics, 1977
- Serology, chemistry, and genetics of O and K antigens of Escherichia coli.1977
- The hitch-hiking effect of a favourable geneGenetics Research, 1974
- The sampling theory of selectively neutral allelesTheoretical Population Biology, 1972