Tiselius Electrophoresis Studies of Plasma Proteins in Diabetes Mellitus

Abstract

Tiselius elec-trophoresis studies of plasma proteins were carried out on 30 patients with diabetes mellitus. In severe uncomplicated diabetic acidosis, the total protein value was normal but albumin was low and [beta]-globulin very high. After treatment and maintenance of good nutrition for mos. the picture became entirely normal. In mild untreated diabetes, the protein distribution was normal but the total protein was slightly decreased. After adequate therapy on a standard diet containing not more than 80 g. of protein, the plasma protein picture became normal. In diabetes complicated by diabetic retinitis the plasma albumin was low despite apparently excellent diabetic control. When patients were placed on a very high protein diet, the picture was restored to nearly normal levels and the eye condition was apparently improved in some instances.