Immunoglobulin production by coeliac biopsies in organ culture.
Open Access
- 1 October 1986
- Vol. 27 (10), 1151-1160
- https://doi.org/10.1136/gut.27.10.1151
Abstract
The production of immunoglobulins by jejunal mucosa during organ culture has been studied. In 18 untreated coeliac patients the amounts of IgA, secretory IgA and IgM in the culture medium were higher than in those from 17 normal controls. The results in 15 treated coeliac patients did not differ from the control subjects. Mucosal biopsies from patients with serum IgA deficiency produced very little IgA, but large amounts of IgG and IgM. The addition of neither Frazer's gluten fraction III, nor alpha-gliadin to the culture system stimulated any additional increased secretion of immunoglobulins from the untreated coeliac patients. Production of IgA and IgM by the small bowel mucosa continues during organ culture, but that of IgG appears insignificant.This publication has 35 references indexed in Scilit:
- Secretion of immunoglobulins and plasma proteins from the jejunal mucosa. Transport rate and origin of polymeric immunoglobulin A.JCI Insight, 1984
- Small intestinal plasma cells in coeliac disease.Gut, 1984
- Quantification of Immunoglobulins After Organ Culture of Human Duodenal MucosaJournal of Pediatric Gastroenterology and Nutrition, 1983
- Jejunal mucosal immunoglobulin-containing cells and jejunal fluid immunoglobulins in adult coeliac disease and dermatitis herpetiformisGut, 1974
- Studies on the quantitation of immunoglobulin in human intestinal secretionsGut, 1973
- Hepatic mixed function oxidase activity in rapidly prepared microsomesLife Sciences, 1972
- Immunoglobulin-containing cells in the coeliac syndromeGut, 1971
- IMMUNOLOGICAL MYSTERY OF CŒLIAC DISEASEThe Lancet, 1969
- Organ culture of mucosal biopsies of human small intestineJCI Insight, 1969
- IMMUNOGLOBULINS IN SERUM AND JEJUNAL BIOPSIES IN NON‐TROPICAL SPRUEActa Medica Scandinavica, 1969