Bruceantin, a potent amoebicide from a plant, Brucea antidysenterica
- 1 August 1982
- journal article
- research article
- Published by American Society for Microbiology in Antimicrobial Agents and Chemotherapy
- Vol. 22 (2), 342-345
- https://doi.org/10.1128/aac.22.2.342
Abstract
Bruceantin, purified from an Ethiopian plant used to treat dysentery, killed Entamoeba histolytica in vitro (IC50 [the concentration of drug which decreased the number of colonies to half that of controls] = 0.018 microgram/ml). Six related quassinoids of 17 tested were also amoebicidal. No relationship between quassinoid structure and amoebicidal activity was apparent.This publication has 9 references indexed in Scilit:
- Inhibition of clonal growth of Giardia lamblia and Entamoeba histolytica by metronidazole, quinacrine, and other antimicrobial agentsJournal of Antimicrobial Chemotherapy, 1981
- Antimalarial Activity of Quassinoids Against Chloroquine-Resistant Plasmodium Falciparum in VitroThe American Journal of Tropical Medicine and Hygiene, 1981
- Clonal Growth of Entamoeba histolytica and other Species of Entamoeba in Agar*The Journal of Protozoology, 1978
- A new medium for the axenic cultivation of Entamoeba histolytica and other EntamoebaTransactions of the Royal Society of Tropical Medicine and Hygiene, 1978
- MODE OF ACTION OF ANTITUMOR COMPOUND BRUCEANTIN, AN INHIBITOR OF PROTEIN-SYNTHESIS1976
- Quassinoid Bitter PrinciplesPublished by Springer Nature ,1973
- The Use of Glaucarubin (a Crystalline Glycoside Isolated from Simarouba Glauca) in the Treatment of Human Colonic AmebiasisThe American Journal of Tropical Medicine and Hygiene, 1956
- Clinical trial of glaucarubin in treatment of amebiasisAmerican Journal Of Medicine, 1956
- ACTION OF ANTIBIOTICS AGAINST INTESTINAL AMOEBAE IN VITROAnnals of the New York Academy of Sciences, 1952