Molecular cloning and amino acid sequence of human enkephalinase (neutral endopeptidase)
- 29 February 1988
- journal article
- Published by Wiley in FEBS Letters
- Vol. 229 (1), 206-210
- https://doi.org/10.1016/0014-5793(88)80828-7
Abstract
We have isolated a cDNA clone encoding human enkephalinase (neutral endopeptidase, EC 3.4.24.11) in a λgt10 library from human placenta, and present the complete 742 amino acid sequence of human enkephalinase. The human enzyme displays a high homology with rat and rabbit enkephalinase. Like the rat and rabbit enzyme, human enkephalinase contains a single N-terminal transmembrane region and is likely to be inserted through cell membranes with the majority of protein, including its carboxy-terminus, located extracellularly.Keywords
This publication has 17 references indexed in Scilit:
- Molecular cloning and amino acid sequence of rat enkephalinaseBiochemical and Biophysical Research Communications, 1987
- Neutral endopeptidase 24.11 in human neutrophils: cleavage of chemotactic peptide.Proceedings of the National Academy of Sciences, 1985
- Human insulin receptor and its relationship to the tyrosine kinase family of oncogenesNature, 1985
- Enzymes in placental microvilli: Angiotensin I converting enzyme, angiotensinase A, carboxypeptidase, and neutral endopeptidase (“enkephalinase”)Peptides, 1984
- Human kidney "enkephalinase", a neutral metalloendopeptidase that cleaves active peptidesBiochemistry, 1983
- Enkephalin Dipeptidyl Carboxypeptidase (Enkephalinase) Activity: Selective Radioassay, Properties, and Regional Distribution in Human BrainJournal of Neurochemistry, 1982
- Properties of “enkephalinase” from rat kidney: Comparison of dipeptidyl-carboxypeptidase and endopeptidase activitiesBiochemical and Biophysical Research Communications, 1982
- Degradation of enkephalins: the search for an enkephalinaseMolecular and Cellular Biochemistry, 1982
- Biological inactivation of enkephalins and the role of enkephalin-dipeptidyl-carboxypeptidase (“enkephalinase”) as neuropeptidaseLife Sciences, 1981
- High-affinity enkephalin-degrading peptidase in brain is increased after morphineNature, 1978