Mechanical strength of acrylic bone cements impregnated with antibiotics
- 1 November 1976
- journal article
- research article
- Published by Wiley in Journal of Biomedical Materials Research
- Vol. 10 (6), 837-845
- https://doi.org/10.1002/jbm.820100603
Abstract
Admixing of several antibiotic powders which were insoluble in methyl methacrylate did not decrease the compressive and diametral tensile strengths of two acrylic bone cements when tested after setting for 1 day and after leaching 40 days in water at 37°C. When antibiotics were added as water solutions, the included water resulted in a significant decrease in these bulk mechanical properties. Storage in water for 40 days caused surface irregularities only on specimens of the set antibiotic admixtures. Approximately 0.5% of the admixed dosage of these water‐soluble antibiotics could be leached from the set cements. The observed surface channels, presumably left by the loss of antibiotic, suggest further study of surface‐sensitive mechanical properties may be needed. The bulk mechanical strengths presented here are conclusive only for the particular combinations of antibiotics and cements investigated, and should not be generalized at this time to any or all antibiotic admixtures or other mechanical properties.This publication has 5 references indexed in Scilit:
- Degree of polymerization of acrylic bone cementJournal of Biomedical Materials Research, 1975
- On the Stability of the Mechanical Properties of Self-Curing Acrylic Bone CementThe Journal of Bone & Joint Surgery, 1974
- On the Setting Properties of Acrylic Bone CementThe Journal of Bone & Joint Surgery, 1973
- Über die Freisetzung von Gentamycin aus Polymethylmethacrylat I. Experimentelle Untersuchungenin vitroLangenbecks Archives Of Surgery, 1972
- Postoperative infection in total prosthetic replacement arthroplasty of the hip-joint with special reference to the bacterial content of the air of the operating roomBritish Journal of Surgery, 1969