In a study of certain cases of the rare condition known as prurigo nodularis, certain histopathologic observations which I have not found noted in the literature suggested that a detailed account of these cases might be of general interest. Hyde1 has given the name of prurigo nodularis to a rare dermatosis characterized by discrete nodules, which vary in color from pink to brownish red, are more or less rounded, vary from the size of a peanut to that of a hazelnut, and are usually located on the extremities, but are occasionally found elsewhere. The lesions are chronic and are associated with intense pruritus. Some of them are verrucous, while others present excoriated surfaces or are covered with adherent scales. The older lesions may be umbilicated. Hardaway,2 in 1880, reported the first case of this unique dermatosis under the title, "A Case of Multiple Tumors of the Skin Accompanied