ROSOXACIN AND CINOXACIN DISTRIBUTION IN PROSTATE, VAGINA, AND FEMALE URETHRA - EXPERIMENTAL-STUDY IN DOGS

Abstract

Rosoxacin and cinoxacin, 2 new compounds structurally related to nalidixic acid, were investigated in dogs. The primary interest was in beneficial effects of the 2 drugs when used to treat urinary tract infections. Distribution of rosoxacin and cinoxacin was investigated in prostatic tissue, prostatic interstitial fluid and prostatic secretion, and in vaginal and female urethral secretions. Concentrations of both antibiotics were also measured in plasma, various tissues and spinal fluid. Amounts of rosoxacin and cinoxacin in all tested tissues, fluids and secretions were in the range of minimal inhibitory concentrations for most gram negative organisms found in urinary tract infections. This suggested possible beneficial effects of the drugs when the infection involves these tissues. Rosoxacin concentration ratios were higher than those of cinoxacin relative to plasma concentration in prostatic, vaginal and urethral secretions, and in prostatic and other tissue. These ratio differences were explained by the 2 drugs, different physiochemical properties 2.