Prenatal detection of neural tube defects. VI. Experience with 20,000 pregnancies
- 19 December 1980
- journal article
- research article
- Published by American Medical Association (AMA) in JAMA
- Vol. 244 (24), 2731-2735
- https://doi.org/10.1001/jama.244.24.2731
Abstract
Neural tube defects (NTDs) are among the most common major congenital malformations in the United States. Prenatal detection is possible in about 95% of cases by assaying amniotic fluid for α-fetoprotein (AFP), which leaks from open lesions. In 20,000 pregnancies, 334 (1.7%) had a raised level of AFP. Of these, 136 (40.7%) had open NTDs, 90 (26.9%) had other fetal defects or conditions, and 108 (32.3%) almost invariably had admixed fetal blood. Pregnancy was electively terminated in 11 cases in which the AFP concentration was thought to be elevated but in which the fetus was apparently normal (0.06%), but in only two of these cases was there no explanation for the raised level of AFP. The practical false-positive rate was considerably below 0.06%. Patients at risk for bearing children with NTDs should be counseled and offered prenatal diagnosis. (JAMA 1980;244:2731-2735)This publication has 5 references indexed in Scilit:
- PRENATAL-DIAGNOSIS OF NEURAL-TUBE DEFECTS .4. MATERNAL SERUM ALPHA-FETOPROTEIN SCREENING1980
- AVOIDANCE OF ANENCEPHALIC AND SPINA BIFIDA BIRTHS BY MATERNAL SERUM-ALPHAFETOPROTEIN SCREENINGThe Lancet, 1978
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- INDICATIONS FOR PRENATAL DIAGNOSIS IN RELATIVES OF PATIENTS WITH NEURAL TUBE DEFECTS1978
- PRENATAL DIAGNOSIS OF NEURAL TUBE DEFECTS .3. RE-EVALUATION OF ALPHA-FETOPROTEIN ASSAY1977