Bone Invasion by Walker 256 Carcinoma, Line A in Young and Adult Rats: Effects of Etidronate
- 1 January 1990
- journal article
- research article
- Published by S. Karger AG in Oncology
- Vol. 47 (2), 160-165
- https://doi.org/10.1159/000226810
Abstract
Line A of Walker 256 carcinoma implanted in the muscle adjacent to the tibia of young (6 weeks) and adult (9 months) male rats invaded the bone. Osteolysis and reactive growth were greater in the bone of young animals than in adults. Ethane-1-hydroxy-1,1-bisphosphonate prevented bone lysis and tumor invasion of the cortex both in young and adult animals. This model may be useful for studies of age-related differences in tumor infiltration into the bone and for investigating drug effects on this process.Keywords
This publication has 8 references indexed in Scilit:
- Effects of intravenous etidronate disodium on skeletal and calcium metabolismThe American Journal of Medicine, 1987
- Effect of etidronate disodium on the interactions between malignancy and boneThe American Journal of Medicine, 1987
- Actions of recombinant interleukin 1, interleukin 2, and interferon-gamma on bone resorption in vitro.The Journal of Immunology, 1986
- AN EXPERIMENTAL RAT MODEL OF LOCAL BONE CANCER INVASION AND ITS RESPONSIVENESS TO ETHANE-1-HYDROXY-1, 1-BIS(PHOSPHONATE)1985
- Production of a Macromolecular Bone-Resorbing Factor by the Hypercalcemic Variant of the Walker Rat Carcinosarcoma*Endocrinology, 1984
- Effects of disodium etidronate in murine tumor modelsEuropean Journal of Cancer and Clinical Oncology, 1984
- Structure-activity relationships of various bisphosphonatesCalcified Tissue International, 1983
- Two Lines of Walker Carcinoma 256: Their Peculiarities and Different Interactions with the HostTumori Journal, 1983