SUCCESSFUL TREATMENT OF ACTINOMYCOSIS WITH "STILBAMIDINE"

Abstract

Crystalline penicillin G has been proposed as the remedy of choice with sulfadiazine as alternate in the treatment of actinomycosis.¹ The two agents have also been used in combination. Streptomycin,² bacitracin,³ and aureomycin⁴ have also been reported to be efficacious. The observation that "stilbamidine" (4,4′-stilbenedicarboxyamidine) was a useful therapeutic agent for infections caused by Blastomyces dermatitidis⁵ prompted its use in a patient with actinomycosis resistant to prolonged administration of penicillin and sulfadiazine. REPORT OF A CASE A 51-year-old white man was admitted to the Veterans Administration Hospital on Jan. 4, 1951, with a mass in the left submental region that had appeared after extraction of a tooth in November, 1950. The tumor had become progressively larger. Pain in the right side of the chest and a cough had been treated by the patient's physician with aureomycin for two days. The patient lost 9 lb. (4.1