FURTHER NOTES ON THE INTERACTION OF SPIRONOLACTONE AND DEOXYCORTICOSTERONE ACETATE IN DOGS
- 1 January 1964
- journal article
- research article
- Published by Oxford University Press (OUP) in Acta Endocrinologica
- Vol. 45 (1), 79-83
- https://doi.org/10.1530/acta.0.0450079
Abstract
Adminstration of DCA induced typical mineralocorticoid effects in a dog, namely the retention of urinary Na and Cl and the loss of K ions. Coadministration of spironolactone orally at several doses neutralized the effect on K, but produced a rate-limited inhibition of Na and Cl retention, by altering tubular reab-sorption of the ions. Plasma levels of spironolactone did not appear to be a factor limiting the Na and Cl response. Interpretation of these data indicates that spironolactone inhibited only one of the tubular reabsorb-ing mechanisms for renal effects of DCA.Keywords
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