Studies on Synthetic Nucleosides V. Anomeric Pyrimidine Nucleosides of D-Arabinose and D-Lyxose

Abstract

Anomeric arabinofuranosyl and lyxofuranosyl nucleosides are synthesized by fusion of acylhalogenosugars with trimethylsilyl derivatives of uracil and thymine followed by removal of the protecting groups. The [alpha]-anomers of the nucleosides are found to be identical with the samples prepared by the mercury procedures. Relationships of optical rotations and nuclear magnetic resonance spectra between the anomers are described.