Strategies for characterization of drug metabolites using liquid chromatography–tandem mass spectrometry in conjunction with chemical derivatization and on-line H/D exchange approaches
- 1 February 2005
- journal article
- review article
- Published by Elsevier in Journal of Pharmaceutical and Biomedical Analysis
- Vol. 37 (1), 1-18
- https://doi.org/10.1016/j.jpba.2004.09.003
Abstract
No abstract availableKeywords
This publication has 68 references indexed in Scilit:
- Strategy for structural elucidation of drugs and drug metabolites using (MS)n fragmentation in an electrospray ion trapJournal of Mass Spectrometry, 2003
- Liquid chromatography/atmospheric pressure ionization–mass spectrometry in drug metabolism studiesJournal of Mass Spectrometry, 2003
- A simultaneous liquid chromatography/mass spectrometric assay of glutathione, cysteine, homocysteine and their disulfides in biological samplesJournal of Pharmaceutical and Biomedical Analysis, 2003
- Addressing the metabolic activation potential of new leads in drug discovery: a case study using ion trap mass spectrometry and tritium labeling techniquesJournal of Mass Spectrometry, 2003
- Recent progress in derivatization methods for LC and CE analysisJournal of Pharmaceutical and Biomedical Analysis, 2002
- Chemical Image Fusion. The Synergy of FT-NIR and Raman Mapping Microscopy To Enable a More Complete Visualization of Pharmaceutical FormulationsAnalytical Chemistry, 2001
- Derivatization in LC/MSYAKUGAKU ZASSHI, 1998
- Quantitative determination of BMS-186716, a thiol compound, in rat plasma by high-performance liquid chromatography-positive ion electrospray mass spectrometry after hydrolysis of the methyl acrylate adduct by the native esterasesJournal of Chromatography B: Biomedical Sciences and Applications, 1997
- Quantitative determination of BMS186716, a thiol compound, in dog plasma by high-performance liquid chromatography–positive ion electrospray mass spectrometry after formation of the methyl acrylate adductJournal of Chromatography B: Biomedical Sciences and Applications, 1997
- Recent Progress in Detection-Oriented DerivatizationYAKUGAKU ZASSHI, 1997