SERUM PROTEINS AND PROTEIN BOUND CARBOHYDRATES IN THE HYPOPHYSECTOMIZED RAT

Abstract

Proteins and glycoproteins of serum were studied after hypophysectomy in the rat. The total serum protein did not show great variations, but the electrophoretic analyses showed a decrease in albumin, and an increase in globulin. The latter was due to an increase in [alpha] 1- and [alpha] 2 globulin immediately after the removal of the gland, and to an increase in gamma-globulin at the end of the experiment. The serum protein-bound hexose, hexosamine and sialic acid increased. Electrophoresis showed an increase in the carbohydrate content of each fraction, especially the [beta]-globulin fraction.