Rabies Viruses Increase in Virulence When Propagated in Neuroblastoma Cell Culture
- 10 March 1978
- journal article
- research article
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 199 (4333), 1072-1075
- https://doi.org/10.1126/science.628831
Abstract
Several strains of attenuated rabies virus lacking the capacity to kill adult mice acquired a high lethal potential for mice after one to five serial passages in murine or human neuroblastoma cells. The virulence acquired after passage in neuroblastoma cells is a stable genetic trait retained during subsequent passage of viruses in nonneuroblastoma cell systems.This publication has 25 references indexed in Scilit:
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