Total Adrenalectomy for Reactivated Carcinoma of the Prostate

Abstract

AN effective new approach to the treatment of neoplastic disease was provided by Huggins and Hodges¹ when they demonstrated the control of cancer of the prostate by orchiectomy and the administration of estrogens. Simultaneously, Munger² achieved a similar though less effective result by radiation of the testes. During the last ten years extensive confirmation of the value of these contributions has been obtained. However, subsequent reactivation of cancer of the prostate after inhibition by hormonal therapy has been a consistent and challenging aspect of the course of the disease. Following the logical assumption that androgens are an activating factor in . . .