Haemoperfusion in the Management of Digoxin Toxicity
- 1 January 1979
- journal article
- review article
- Published by Springer Nature in Clinical Pharmacokinetics
- Vol. 4 (5), 395-399
- https://doi.org/10.2165/00003088-197904050-00005
Abstract
Several recent publications have encouraged the use of haemoperfusion to remove digoxin from the body of overdosed patients. The usefulness of haemoperfusion in removing digoxin from the body has therefore been examined using pharmacokinetic simulation techniques and published data. Haemoperfusion for a period of 4 hours with a clearance of 100ml/min removes less than 7% of the amount of digoxin in the body (including that in the gastrointestinal tract at the beginning of haemoperfusion), regardless of the time after the dose that haemoperfusion is started. Dramatic therapeutic benefit in digoxin intoxication is unlikely to be a consequence of the amount of digoxin removed from the body by haemoperfusion. If therapeutic benefit is derived from a transient decline of digoxin concentration in plasma, it may be expected to be negated as the drug redistributes from tissues.This publication has 12 references indexed in Scilit:
- Advanced Digoxin Toxicity in Renal FailureSouthern Medical Journal, 1979
- Resin Hemoperfusion in Acute Digoxin IntoxicationJAMA, 1978
- Hemoperfusion in Drug OverdosePublished by American Medical Association (AMA) ,1978
- HEMOPERFUSION REMOVAL OF DIGOXIN FROM DOGS1978
- Hemoperfusion in digitalis intoxication: a comparative study of coated versus uncoated charcoal.1977
- Clinical Pharmacokinetics of DigoxinClinical Pharmacokinetics, 1977
- TREATMENT OF SEVERE DRUG OVERDOSAGE WITH CHARCOAL HEMOPERFUSIONAsaio Journal, 1977
- Treatment of digitalis intoxication by charcoal hemoperfusion (CHP).1976
- Bioavailability of digoxin from tablets. II. Radioimmunoassay and disposition pharmacokinetics of digoxin after intravenous administration.1974
- Role of Pharmacokinetics in Drug Dosage Adjustment. I. Pharmacologic Effect Kinetics and Apparent Volume of Distribution of DigoxinThe Journal of Clinical Pharmacology and New Drugs, 1973