Neurohumoral regulation of blood flow to bones and marrow
- 1 October 1979
- journal article
- research article
- Published by American Physiological Society in American Journal of Physiology-Heart and Circulatory Physiology
- Vol. 237 (4), H440-H448
- https://doi.org/10.1152/ajpheart.1979.237.4.h440
Abstract
We used labeled microspheres to measure bone and marrow blood flow under control conditions and during several interventions. In dogs, blood flow to compact cortical bone (femoral diaphysis) was 2 +/- 0.1 ml.min-1. 100 g-1, and in hematopoietic marrow (femur), flow was 24 +/- 5 ml.min-1. 100 g-1. Hematopoietic cancellous bones (sternum, ilium) received substantial blood flow. We estimate that as much as 11% of cardiac output is directed to the skeleton. Bone and marrow vessels were responsive to several stimuli. During exercise, vascular resistance in bone increased two- to fourfold, in contrast to profound vasodilation in adjacent skeletal muscle. Hemmorrhage also increased bone vascular resistance. Bone and marrow vessels responded to humoral stimuli: norepinephrine increased vascular resistance and adenosine decreased resistance. Bone vessels also responded to neural stimuli: stimulation of carotid baroreceptors decreased vascular resistance, and activation of sympathetic pathways by baroreceptor deafferentation in cats increased vascular resistance. These studies indicate that bone and marrow vessels respond actively to physiological stresses and to several humoral and neurogenic stimuliThis publication has 9 references indexed in Scilit:
- Regulation of Blood Flow to the Aortic Media in DogsJCI Insight, 1978
- The effect of hypoxia on the regional distribution of cardiac output in the dog.Circulation Research, 1976
- The Clinical Measurement of Skeletal Blood FlowClinical Science, 1976
- Total and regional cerebral blood flow measurement with 7-10-, 15-, 25-, and 50-mum microspheresJournal of Applied Physiology, 1976
- Extraction Ratio and Bone Clearance of Sr 85 as a Measure of Effective Bone Blood FlowCirculation Research, 1965
- The Effect of Sympathectomy on Blood Flow to BoneJAMA, 1963
- A study of blood flow through bone marrow by a method of venous effluent collectionThe Journal of Physiology, 1962
- Innervation of the vessels of the marrow cavity of certain bonesAmerican Journal of Physiology-Legacy Content, 1959
- STUDIES ON THE BONE MARROW CAVITY OF THE DOG - FAT EMBOLISM AND MARROW PRESSURE1952