Cleavage of yeast tRNAPhe with complementary oligonucleotide conjugated to a small ribonuclease mimic
- 20 September 2000
- journal article
- Published by Wiley in FEBS Letters
- Vol. 481 (3), 277-280
- https://doi.org/10.1016/s0014-5793(00)02029-9
Abstract
An oligonucleotide conjugate bearing a chemical construct mimicking the catalytic center of ribonuclease A has been designed and studied. The conjugate efficiently cleaves yeast tRNAPhe at a single site adjacent to the target complementary sequence.Keywords
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