The Demonstration of Mucopolysaccharide Inclusions in the Lymphocytes of Patients with Gargoylism

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Abstract
A method has been described for staining lymphocytic inclusions in patients with gargoylism. Films of peripheral blood are stained with May-Gruenwald-Glemsa and with toluidine blue. The inclusions, which are present only in a proportion of the lymphocytes, stain red to purple with May-Gruenwald-Giemsa and metachromatically with toluidine blue. The demonstration of these inclusions has been shown to be of considerable value in the diagnosis of gargoylism.