CONVULSANT EFFECTS OF ISONIAZID

Abstract

This report is the first collaborative effort of members of a university department of pharmacology, the staff of a state hospital, and the psychiatric division of another university faculty. Although we have outlined a coordinated research program, we do not assume that the degree of communication necessary for multidisciplinary research has yet been achieved. Data and information are being gathered and consolidated so that the common biological principles involved in our respective disciplines can eventually be more clearly formulated. In the meantime, we are utilizing common observations for emphasizing various perspectives on some similar problems. The pharmacologist is interested in studying the biochemical factors in epilepsy and identifying more effective chemotherapeutic agents for schizophrenic patients.¹ The psychiatrist makes the basic assumption that changes in the internal milieu will be reflected in behavioral alterations. Since the hydrazides alter cerebral cortical functions and produce electroencephalographic evidence of this alteration, this class