Coronary Angiography and Acute Renal Failure in Diabetic Azotemic Nephropathy

Abstract

Thirteen juvenile-onset diabetics with azotemic diabetic nephropathy (mean serum creatinine level, 6.8 mg/dl) being evaluated for renal transplantation underwent cardiac catheterization with angiography [to diagnose myocardial ischemia]. All were followed for development of acute renal failure. Twelve (92%) developed some evidence of acute renal failure. Two required K exchange resin therapy. Six required dialysis acutely. There were no deaths. All patients who received greater than 65 ml/m2 of iodinated contrast developed acute renal failure. No patient with a Hb value greater than 9.9 g/dl required dialysis or K exchange resin. The single patient without acute renal failure received less than 50 ml/m2 of iodinated contrast and had the highest Hb value (12.0 g/dl). No cardiac or angiographic variables were predictive of acute renal failure. In this group at high risk for acute renal failure, radiographic contrast procedures should only be done if the information to be obtained is weighed against the potential for injury.