Metabolism of Gr51 by Animals as Influenced by Chemical State.

Abstract

The physiol. behavior of trivalent and hexavalent Cr has been observed over a 45-day period in rats as affected by chemical form and route of admn. When intraven. admn. as Na chromite, practically 100% of the dose was picked up by the organs of the reticuloendothelial system. Chromic chloride results in a pickup by the liver of about 55% of the dose. When Cr51Cl3 was added to isotonic acetate and citrate buffers, less than 5% of tne dose reached the liver and most of the activity was excreted in the urine. About 25% of the dose of Na chromate solns. reached the liver. However, the activity left this organ rapidly in contradistinction to the other forms studied. Oral, intraperit., and intratrach. admn. of C15C13 were also studied. None of the forms of Cr51 used crossed the placenta of rats ranging from 15 to 20 days in gestation. In addition, data are presented from 2 sheep intraven. dosed with Cr15 cl3. The above physiol. observations are correlated with the colloidal behavior, complex formation, protein binding, and red cell binding, and are in general agreement with interpretations of filter paper electrophoretic studies of the dosing solns.