Induction of Renal Glomerular Lesions by Urethane in Inbred Mice Susceptible to Spontaneous Glomerulonephritis.

Abstract

Urethane induced glomerular lesions in NH mice, an inbred strain which is susceptible to the spontaneous development of glomerulonephritis. Mice with the urethane-induced glomerular alterations exhibited renal insufficiency, albuminuria, edema, and depressed plasma protein levels. One case evidenced hypercholesterolemia.