Regional Enteritis and Granulomatous Colitis Associated with Erythrocyte Glucose-6-Phosphate Dehydrogenase Deficiency

Abstract

THE simultaneous occurrence of two uncommon diseases in several families originating from a relatively circumscribed geographical region suggests a relation. Erythrocyte glucose-6-phosphate dehydrogenase deficiency is due to a group of related mutations of enzyme structure or rate of synthesis, all inherited as sex-linked characteristics. The incidence varies from less than 0.5 per cent in males of northern European origin to over 20 per cent in certain oriental Jewish groups.¹ Regional enteritis and granulomatous colitis appear to be closely related forms of chronic granulomatous disease of unknown origin, one affecting primarily the small intestine and the other, apparently the same process, . . .