THE REMOVAL OF SODIUM CHOLATE FROM THE BLOOD AND ITS SECRETION INTO THE BILE AS AFFECTED BY THYROXINE

Abstract

The removal of Na cholate from the blood, its excretion in the urine, and its secretion into the bile were studied in normal and thyroxine treated rabbits. Na cholate was rapidly removed from the blood of normal rabbits. Treatment with thyroxine retarded the rate of removal; this delay was greater in the rabbits receiving the larger amts. of thyroxine. The amt. of Na cholate excreted in the urine was essentially the same in the normal and treated rabbits and was only a small portion of the total Na cholate injected. Thyroxine treatment did not affect the vol. of bile or the concs. of cholic and deoxycholic acids secreted under normal circumstances. Following the in-traven. inj. of cholate rabbits treated with thyroxine did not secrete this bile salt into the bile as rapidly as did normal rabbits. This was due to the inability of the treated animals to secrete as large a vol. or as conc. a bile as that of normal animals.