Beta-Lactamase Activity in Strains of Bacteroides melaninogenicus and Bacteroides oralis
Open Access
- 1 January 1977
- journal article
- research article
- Published by American Society for Microbiology in Antimicrobial Agents and Chemotherapy
- Vol. 11 (1), 142-146
- https://doi.org/10.1128/aac.11.1.142
Abstract
β-Lactamase from strains of Bacteroides melaninogenicus and Bacteroides oralis hydrolyzed penicillin more rapidly than ampicillin or carbenicillin. Cephalothin and a chromogenic cephalosporin (87/312) were also hydrolyzed by the enzyme. Activity was found only in β-lactam-resistant strains, but there was considerable variation in activity among strains having the same minimal inhibitory concentrations of antibiotic. β-Lactamase activity was cell bound and appeared to be tightly associated with the cell envelope since detergents were required to elute this activity.Keywords
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