Lack of allelic association between 102T/C polymorphism of serotonin receptor type 2A gene and schizophrenia in Chinese

Abstract

Recent studies have reported an association between a 102T/C polymorphism of serotonin receptor type 2A gene (5-HT24) and schizophrenia. In addition, an association was detected between a 102T/C polymorphism of the 5-HT24 receptor gene and drug response to clozapine in the treatment of schizophrenic patients. These studies suggest an important role of the 5-HT24 gene in schizophrenia. To study the possible involvement of the 5-HT24 gene in the pathogenesis of schizophrenia, a case-control association study was carried out in a Chinese population from Taiwan. No significant differences of genotype distributions, allele frequencies and homozygosity were detected between schizophrenic patients (n = 177) and non-psychiatric controls (n = 98). When subjects were divided into subgroups according to sex, still no differences of allele frequencies or genotype distributions were noted between patients and controls. Our data do not support an allelic association between the 102T/C polymorphism of the 5-HT24, receptor gene and schizophrenia in Chinese population.