Regulation of arginase activity by intermediates of the arginine biosynthetic pathway in Neurospora crassa.
- 1 June 1972
- journal article
- Vol. 110 (3), 870-7
Abstract
It has been found that, in Neurospora crassa, arginine synthesized from exogenous citrulline was not as effectively hydrolyzed as exogenous arginine. This was explained by the observed inhibition of arginase in vitro and in vivo by citrulline. The high arginine pool formed from exogenous citrulline feedback inhibits the arginine pathway. These two factors allow exogenous citrulline to be used adventitiously and efficiently as an arginine source. Finally, it was found that ornithine was a strong inhibitor of arginase. This suggests that the characteristically high ornithine pool of minimal cultures of Neurospora may act to control a potentially wasteful catabolism of endogenous arginine by arginase.This publication has 12 references indexed in Scilit:
- Induction and Repression of the Histidine-degrading Enzymes of Bacillus subtilisJournal of Biological Chemistry, 1968
- The catabolism of l-arginine by Neurosora crassaBiochimica et Biophysica Acta (BBA) - General Subjects, 1967
- On the structure and function of different arginasesBiochimica et Biophysica Acta (BBA) - Enzymology and Biological Oxidation, 1966
- A mutant form of ornithine transcarbamylase found in a strain of Neurospora carrying a pyrimidine-proline suppressor geneArchives of Biochemistry and Biophysics, 1962
- Arginine Synthesis in Neurospora crassa; Genetic StudiesJournal of General Microbiology, 1957
- DETERMINATION OF CREATINE, CREATININE, ARGININE, GUANIDINOACETIC ACID, GUANIDINE, AND METHYL-GUANIDINE IN BIOLOGICAL FLUIDSJournal of Biological Chemistry, 1956
- ON THE GLUTAMATE-PROLINE-ORNITHINE INTERRELATION IN NEUROSPORA CRASSAProceedings of the National Academy of Sciences, 1954
- PROTEIN MEASUREMENT WITH THE FOLIN PHENOL REAGENTJournal of Biological Chemistry, 1951