HLA‐DR factors associated with postpartum hypothyroidism : an early manifestation of Hashimoto's thyroiditis?
- 1 July 1987
- journal article
- research article
- Published by Wiley in Tissue Antigens
- Vol. 30 (1), 34-37
- https://doi.org/10.1111/j.1399-0039.1987.tb01593.x
Abstract
Thirty-three Danish women selected from a prospective study of postpartum thyroiditis were HLA-DR typed. All women had positive titers of antimicrosomal antibodies, and 20 women developed thyroid dysfunction after delivery. DR5 and the phenotype 4,5 were siginficantly increased in the whole group (p < 0.001) and strongly associated to hypothyroidism (p < 0.01), whereas DR3 was insignificantly increased in thyrotoxic women. It is concluded that postpartum hypothyroidism is an autoimmune disorder and may be an early manifestation of Hashimoto''s thyroiditis.This publication has 7 references indexed in Scilit:
- Thyroid Dysfunction after Delivery: Incidence and Clinical CourseActa Medica Scandinavica, 1987
- Influence of the HLA-DR4 Antigen and Iodine Status on the Development of Autoimmune Postpartum Thyroiditis*Journal of Clinical Endocrinology & Metabolism, 1985
- Autoimmune Thyroid Dysfunction in the Postpartum Period*Journal of Clinical Endocrinology & Metabolism, 1984
- Postpartum autoimmune thyroid disorder associated with HLA‐DR4?Tissue Antigens, 1984
- INCREASED FREQUENCY OF HLA‐DR3 AND 5 IN THE SYNDROMES OF PAINLESS THYROIDITIS WITH TRANSIENT THYROTOXICOSIS: EVIDENCE FOR AN AUTOIMMUNE AETIOLOGYClinical Endocrinology, 1983
- High Prevalence of Transient Post-Partum Thyrotoxicosis and HypothyroidismNew England Journal of Medicine, 1982
- HLA-DR phenotype and HLA-B,DR haplotype frequencies in 704 unrelated DanesTissue Antigens, 1981