Molecular mimicry: frequency of reactivity of monoclonal antiviral antibodies with normal tissues
- 1 January 1986
- journal article
- Published by American Society for Microbiology in Journal of Virology
- Vol. 57 (1), 397-401
- https://doi.org/10.1128/jvi.57.1.397-401.1986
Abstract
More than 600 monoclonal antiviral antibodies made against 11 different viruses were screened against 14 different organs from normal uninfected mice. Of these antiviral antibodies, 21, or approximately 3.5%, reacted with specific cells in these organs. Several of these antibodies were of the multiple-organ-reactive type and recognized antigens in more than one organ. It was concluded that the reactivity of monoclonal antiviral antibodies with normal tissues is a common phenomenon.Keywords
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