Large-scale manufacture of peptide therapeutics by chemical synthesis
Top Cited Papers
- 1 July 2003
- journal article
- review article
- Published by Springer Nature in Nature Reviews Drug Discovery
- Vol. 2 (7), 587-593
- https://doi.org/10.1038/nrd1133
Abstract
The large-scale commercial production of a 36-amino-acid peptide by chemical synthesis has been demonstrated in the development of enfuvirtide (T-20 or Fuzeon), a first-in-class membrane fusion inhibitor for the treatment of HIV. The rationale behind route selection and the scale-up of the process used to manufacture enfuvirtide are discussed.Keywords
This publication has 21 references indexed in Scilit:
- Principles of Peptide SynthesisPublished by Springer Nature ,1993
- Solid phase peptide synthesis utilizing 9‐fluorenylmethoxycarbonyl amino acidsInternational Journal of Peptide and Protein Research, 1990
- Solid-phase synthesis of protected peptide fragments using a trialkoxy-diphenyl-methylester resin.Tetrahedron Letters, 1987
- SOLID‐PHASE PEPTIDE SYNTHESIS USING MILD BASE CLEAVAGE OF NαFLUORENYLMETHYLOXYCARBONYLAMINO ACIDS, EXEMPLIFIED BY A SYNTHESIS OF DIHYDROSOMATOSTATINInternational Journal of Peptide and Protein Research, 1978
- A mild procedure for solid phase peptide synthesis: use of fluorenylmethoxycarbonylamino-acidsJournal of the Chemical Society, Chemical Communications, 1978
- Application of polyamide resins to polypeptide synthesis: an improved synthesis of β-endorphin using fluorenylmethoxycarbonylamino-acidsJournal of the Chemical Society, Chemical Communications, 1978
- New amino-protecting groups in organic synthesisAccounts of Chemical Research, 1973
- 9-Fluorenylmethoxycarbonyl amino-protecting groupThe Journal of Organic Chemistry, 1972
- 9-Fluorenylmethoxycarbonyl function, a new base-sensitive amino-protecting groupJournal of the American Chemical Society, 1970
- Solid Phase Peptide Synthesis. I. The Synthesis of a TetrapeptideJournal of the American Chemical Society, 1963