GLC Determination of Pseudoephedrine and Related Ephedrines in Serum as The Heptafluorobutyryl Derivatives

Abstract

A method capable of determining therapeutic blood levels of pseudoephedrine in man is described. The procedure involves partial purification by extraction, formation of the heptafluorobutyryl derivative, and electron capture detection of the prepared derivatives. Serum levels of pseudoephedrine in man are presented. Chemical reactivity, stability and gas chromatographic properties of the ephedrine derivatives are discussed.