Multiple Sclerosis and Amyotrophic Lateral Sclerosis

Abstract

Amyotrophic Lateral SclerosisClinical and Pathological CharacteristicsAmyotrophic lateral sclerosis is used here synonymously with the term "progressive motor-system disease." With its clinical components, progressive muscular atrophy and progressive bulbar palsy, it is a disease in which slowly progressive degeneration of anterior-horn cells in the spinal cord and of motor nuclei in the brain stem is the most prominent feature. Betz cells in the motor cortex may also degenerate, with secondary degeneration of the corticospinal and corticobulbar tracts.²⁷ Muscular atrophy, which is secondary to lesions of the motor cells of the spinal cord, is nearly always pronounced at the time . . .