Synthesis and pharmacological properties of a series of antidopaminergic piperidyl benzamides
- 1 September 1977
- journal article
- research article
- Published by Oxford University Press (OUP) in Journal of Pharmacy and Pharmacology
- Vol. 29 (1), 147-152
- https://doi.org/10.1111/j.2042-7158.1977.tb11272.x
Abstract
The synthesis and pharmacological screening for anti-apomorphine, stomach emptying and local anaesthetic activities of some new piperidylbenzamides is described. One of these, N-(1′-benzyl-4′-piperidyl)-2-methoxy-4-amino-5-chlorobenzamide (clebopride) is more potent than metoclopramide in tests related to blockade of cerebral dopamine receptors.This publication has 13 references indexed in Scilit:
- Rearrangements during the synthesis of substituted 1-benzylpyrrolidines and 3-substituted 1-benzylpiperidinesJournal of the Chemical Society, Perkin Transactions 1, 1976
- Comparative Psychotropic Effects of Metoclopramide and Prochlorperazine in Normal SubjectsThe Journal of Clinical Pharmacology, 1975
- Pharmacological evidence for cerebral dopamine receptor blockade by metoclopramide in rodentsPsychopharmacology, 1975
- Metoclopramide Induces Catalepsy and Increases Striatal Homovanillic Acid Content in MiceActa Pharmacologica et Toxicologica, 1974
- Benzamidopiperidines. 3. Carbocyclic derivatives related to indoraminJournal of Medicinal Chemistry, 1974
- Changes in dopamine agonist and antagonist activity floowing temporary inactivation of the neostriatumNaunyn-Schmiedebergs Archiv für experimentelle Pathologie und Pharmakologie, 1974
- Is there a relationship between the involvement of extrapyramidal and mesolimbic brain areas with the cataleptic action of neuroleptic agents and their clinical antipsychotic effect?Psychopharmacology, 1973
- Dystonic Reactions in Children Caused by MetoclopramideArchives of Disease in Childhood, 1970
- Gastrointestinal Actions of MetoclopramideGastroenterology, 1967
- The Chemistry and Pharmacology of Some 4-Aminopiperidines and Their Derivatives1aJournal of Medicinal Chemistry, 1964