Regeneration of Locally Irradiated Bone Marrow. II. Induction of Regeneration in Permanently Aplastic Medullary Cavities

Abstract

Marrow cavities permanently aplastic after irradiation were mechanically disrupted and locally injected with bone marrow obtained from an opposite leg. Hemopoietic bone marrow regenerated with restoration of normal parenchymal and sinusoidal architecture. Mechanical disruption alone or intravenous transfusions of isogeneic bone marrow alone failed to induce any evidence of regeneration of the aplastic marrow.