A method for the preparation of films of oriented DNA is described. It involves as a first stage the wet spinning of DNA and as a 2nd stage the drying of the spun DNA deposit to an apparently homogenous film. The method is convenient for the preparation of large samples which are suitable for physico-chemical investigations of oriented DNA. Birefringence, dichroism and X-ray diffraction pattern all indicate that the molecular orientation of the films is very good.