Ethanol acceptance as a function of genotype amounts of brain [Met]enkephalin.
- 1 November 1983
- journal article
- research article
- Published by Proceedings of the National Academy of Sciences in Proceedings of the National Academy of Sciences
- Vol. 80 (21), 6510-6512
- https://doi.org/10.1073/pnas.80.21.6510
Abstract
A negative correlation is indicated between the amount of ethanol (10%) comsumed and endogenous levels of brain [Met]enkephalin in C57BL/6J (alcohol-preferring) and DBA/2J (alcohol-nonpreferring) inbred mice strains. Eight weeks after 1-day starved groups of both C57BL/6J and DBA/2J mice were challenged with ethanol (10%) for 1-day acceptance, they had significantly lower levels of brain [Met]enkephalin compared with their nonalcohol-treated controls. The brain endogenous peptidyl opiates may play a crucial role in alcohol-seeking behavior.This publication has 15 references indexed in Scilit:
- Alcohol and the Opiate ReceptorAlcohol, Clinical and Experimental Research, 1983
- Naloxone alters alcohol drinking induced in the rat by tetrahydropapaveroline (THP) infused ICVPharmacology Biochemistry and Behavior, 1982
- Suppression of ethanol consumption by MET-enkephalin in ratsJournal of Pharmacy and Pharmacology, 1982
- Multiple Opiate Receptors: Alcohol Selectively Inhibits Binding to Delta ReceptorsScience, 1981
- Ethanol preference as a function of genotypic levels of whole brain enkephalin in mice.1981
- Alcohol-related tetrahydroisoquinolines: pharmacology and identification.1980
- Opiate-like activity of salsolinol on the electrically stimulated guinea pig ileumLife Sciences, 1979
- INTERACTIONS OF NARCOTICS, NARCOTIC ANTAGONISTS, AND ETHANOL DURING ACUTE, CHRONIC, AND WITHDRAWAL STATES*Annals of the New York Academy of Sciences, 1976
- Ethanol preference in the hamster: effects of morphine sulfate and naltrexone, a long-acting morphine antagonist.1976
- Morphine-induced Suppression of Voluntary Alcohol Drinking in RatsNature, 1973