STUDIES OF SOME INFLAMMATORY AND IMMUNOLOGICAL RESPONSES OF DIFFERENT STRAINS OF RAT

Abstract

Differences were observed in the severity of AA [adjuvant-induced arthritis] in 4 inbred strains of rats. The interindividual correlation of the primary and secondary lesions showed an inverse relationship between the gravity of the primary and secondary lesions in the LEW and LE strains. WAG strain appeared to be the lowest responder in the intensity of the primary and secondary edema in AA and in carrogeenan edema. This is in agreement with the low vascular permeability of this strain after PGE2 [prostaglandin E2] injection. When the values of the immunological tests in the individual strains (LE, WAG, LEW) were compared there was a reciprocal inverse relationship between them and the intensity of the secondary lesion. The induction of AA apparently requires very precise conditions, indicating that they might depend on a critical state of immune reactivity and on the action of the pharmacologic mediators.